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This research explores the role of AMIGO2 in liver metastasis through extracellular vesicles (EVs). It highlights how AMIGO2 loading correlates with EV secretion, enhancing tumor-endothelial adhesion and initiating hepatic sinusoid targeting. Additionally, it examines EV-driven remodeling of the pre-metastatic niche, where AMIGO2-sEVs activate hepatic stellate cells, leading to IL-8 secretion that promotes gastric cancer cell migration. Future experiments aim to validate these mechanisms in...