TLR2/1/6 Signaling in Neurosphere-Derived Neurons and Neuroimmune Interaction

This research delves into the role of Toll-Like Receptors (TLR2/1/6) in neuroinflammatory processes and their implications in Parkinson’s Disease (PD) pathogenesis, employing neurospheres as an in-vitro model. Key analyses include neuronal differentiation, ligand-induced TLR activation, and downstream signaling pathways (MAPK, PI3K/AKT). The study involves western blot, ICC, and statistical methods to investigate TLR expression, functional localization, and neuroimmune interactions under...