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This study explores the role of AMIGO2 in liver metastasis, highlighting its higher expression in liver lesions and its involvement in endothelial attachment. It also examines how small extracellular vesicles (sEVs) contribute to a pre-metastatic niche by facilitating AMIGO2 uptake in hepatic stellate cells (HSCs) and activating NF-κB signaling, which is linked to IL-8 secretion and cancer-cell migration. The implications of these findings are discussed, including comparisons between gastric...