Enhancing CAR-T Cell Therapy with IL-7 for Tumor Persistence

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This research explores integrating IL-7 into CAR-T cell therapy to address challenges of persistence and oxidative exhaustion in treating blood cancers. IL-7 enhances CAR-T function by promoting stem-like phenotypes, increasing diversity, and reducing exhaustion markers. It optimizes glycolysis and amino acid metabolism, improving cellular efficiency. In vitro and in vivo studies demonstrate prolonged survival, reduced tumor burden, and balanced CD4/CD8 ratios. Mechanistic insights highlight...