HPiP: Predicting Host-Pathogen Protein Interactions

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This presentation focuses on infectious diseases and the critical role of host-pathogen protein-protein interactions (HP-PPIs) in understanding infection mechanisms. It introduces the HPiP package, leveraging ensemble machine learning methods and protein sequence descriptors within an automated workflow. Case studies, including SARS-CoV-2 and Mycobacterium tuberculosis PPIs, showcase novel predictions and experimental validations. The results highlight enhanced classifier accuracy,...