A 3D In Vitro Model for Studying Human Implantation and Implantation Failure

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This research project presents an innovative 3D model using blastoids and endometrioids to mimic embryo implantation and development. Through a scalable and ethical platform, the study employs microfluidic chips for co-culturing, advancing understanding of Recurrent Implantation Failure (RIF). Key findings include successful implantation, single-cell transcriptomics insights, and FDA-approved compound screenings for RIF therapy. The 3D model elucidates embryo-endometrium interactions,...