A widely used and effective layout includes these sections deckary.com deckary.com +1 : Title & Context (1 slide) Case title, client/subject name, and brief scope. Use a clean, bold header and a relevant image or icon. Problem Statement (1–2 slides) Describe the challenge, gap, or risk. Use visuals (charts, before images) to show the “before” state. Solution Approach (2–3 slides) Outline methodology, tools, or strategies. Include process diagrams, timelines, or key steps. Results & Impact (2–3 slides) Present measurable outcomes with data, metrics, and comparisons. Use “before vs. after” visuals for contrast deckary.com deckary.com . Testimonial / Takeaway (1 slide) Client quote, stakeholder feedback, or key lesson learned. Next Steps / Call to Action (1 slide) Suggest future actions, partnerships, or follow-ups. ------- here is the article i pulled from online ----- Background Stevens–Johnson syndrome (SJS) is a known, but rare adverse effect of Lamotrigine, occurring in less than 0.1% of the population. Rapid dose titrations of Lamotrigine, an antiepileptic used off-label for the treatment of bipolar disorder, have been shown to increase the risk of SJS, and in even rarer cases, progression to toxic epidermal necrolysis (TEN), which currently has too few cases to report an estimated incidence. Data suggest that additional factors, including female sex and certain HLA alleles associated with East and Southeast Asian ancestries, may be associated with increased risk of Lamotrigine-induced SJS/TEN. Case presentation This case presents a 26-year-old Southeast Asian female with bipolar I disorder who developed SJS shortly after her Lamotrigine dose was titrated appropriately from 50 milligrams (mg) to 100 mg daily, which rapidly progressed to TEN. The patient received treatment, including steroids, intravenous (IV) immunoglobulin, and surgical debridement, and was discharged home in stable condition after 8 days. Conclusion This case prompts consideration of sex and ancestry when identifying high-risk populations taking Lamotrigine. Continued research into sex- and ancestry-based pharmacogenomics may reduce the incidence of these life-threatening reactions. 1. Introduction Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a life-threatening spectrum of desquamating rashes of the skin and mucous membranes [1]. These rare dermatologic emergencies are associated with significant morbidity and mortality. Estimated mortality rates from 2010 to 2020 were 5.4% and 15.3% for SJS and TEN, respectively [2]. These conditions are commonly associated with medication use, including Lamotrigine, an antiseizure medication, which is widely used off-label as a mood stabilizer to treat bipolar disorder [3]. Lamotrigine-associated SJS and TEN most often occur 2–8 weeks after medication initiation. In adults, studies report up to a 0.08% incidence of Lamotrigine-associated SJS, and as of 2023, the number of cases of Lamo
A widely used and effective layout includes these sections deckary.com deckary.com +1 : Title & Context (1 slide) Case title, client/subject name, and brief scope. Use a clean, bold header and a relevant image or icon. Problem Statement (1–2 slides) Describe the challenge, gap, or risk. Use visuals (charts, before images) to show the “before” state. Solution Approach (2–3 slides) Outline methodology, tools, or strategies. Include process diagrams, timelines, or key steps. Results & Impact (2–3 slides) Present measurable outcomes with data, metrics, and comparisons. Use “before vs. after” visuals for contrast deckary.com deckary.com . Testimonial / Takeaway (1 slide) Client quote, stakeholder feedback, or key lesson learned. Next Steps / Call to Action (1 slide) Suggest future actions, partnerships, or follow-ups. ------- here is the article i pulled from online ----- Background Stevens–Johnson syndrome (SJS) is a known, but rare adverse effect of Lamotrigine, occurring in less than 0.1% of the population. Rapid dose titrations of Lamotrigine, an antiepileptic used off-label for the treatment of bipolar disorder, have been shown to increase the risk of SJS, and in even rarer cases, progression to toxic epidermal necrolysis (TEN), which currently has too few cases to report an estimated incidence. Data suggest that additional factors, including female sex and certain HLA alleles associated with East and Southeast Asian ancestries, may be associated with increased risk of Lamotrigine-induced SJS/TEN. Case presentation This case presents a 26-year-old Southeast Asian female with bipolar I disorder who developed SJS shortly after her Lamotrigine dose was titrated appropriately from 50 milligrams (mg) to 100 mg daily, which rapidly progressed to TEN. The patient received treatment, including steroids, intravenous (IV) immunoglobulin, and surgical debridement, and was discharged home in stable condition after 8 days. Conclusion This case prompts consideration of sex and ancestry when identifying high-risk populations taking Lamotrigine. Continued research into sex- and ancestry-based pharmacogenomics may reduce the incidence of these life-threatening reactions. 1. Introduction Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a life-threatening spectrum of desquamating rashes of the skin and mucous membranes [1]. These rare dermatologic emergencies are associated with significant morbidity and mortality. Estimated mortality rates from 2010 to 2020 were 5.4% and 15.3% for SJS and TEN, respectively [2]. These conditions are commonly associated with medication use, including Lamotrigine, an antiseizure medication, which is widely used off-label as a mood stabilizer to treat bipolar disorder [3]. Lamotrigine-associated SJS and TEN most often occur 2–8 weeks after medication initiation. In adults, studies report up to a 0.08% incidence of Lamotrigine-associated SJS, and as of 2023, the number of cases of Lamo
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This case study discusses a 26-year-old Southeast Asian woman with bipolar I disorder who developed Stevens-Johnson syndrome (SJS) after titrating lamotrigine. The condition rapidly progressed to toxic epidermal necrolysis, necessitating treatment with steroids, IVIG, and debridement, ultimately stabilizing her condition. After 8 days, she was discharged in stable condition. Key takeaways emphasize the importance of assessing sex and ancestry in risk factors and advancing pharmacogenomic...