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The SHINE trial investigated the impact of intensive glucose control on acute stroke patients, addressing hyperglycemia's role in inflammation and oxidative stress. Conducted across 63 US sites, 1,151 adults were randomized to receive either intensive IV insulin targeting 80-130 mg/dL or standard sliding-scale insulin targeting 80-179 mg/dL. Most participants had type 2 diabetes, with a median glucose level of 188 mg/dL. The primary outcome measured was the severity-adjusted 90-day modified...