Seqwish: Unbiased Pangenome Graph Construction Algorithm

This research explores the seqwish algorithm for unbiased pangenomics, highlighting its computational efficiency, lossless compression, and scalability. It addresses limitations in current graph methods by introducing key concepts such as alignments and match closures. Experimental results across species demonstrate seqwish's performance, alignment sensitivity, and superiority over existing tools. The study emphasizes seqwish's contributions, potential applications, and future directions in...