Acute-on-Chronic Liver Failure: Mechanisms and Management

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The presentation delves into Acute-on-Chronic Liver Failure (ACLF), characterized by acute decompensation on pre-existing chronic liver disease, with outcomes significantly influenced by systemic inflammation and hepatic functional capacity. It covers the different definitions and classifications, such as those by APASL and EASL–CLIF, and prognostic scoring systems like MELD and CLIF-C. We examine the etiological factors, pathophysiology involving immune dysregulation, and systemic...