Integrating Efficacy and Toxicity in Cancer Treatment
Integrating Efficacy and Toxicity in Cancer Treatment
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The project focuses on developing a Parallel irAE Prediction Model that integrates immune-related adverse event (irAE) risk prediction with SCORPIO efficacy modeling. It aims to define specific prediction targets for irAEs while assessing the net clinical benefit by combining efficacy and toxicity. The study utilizes blood biomarkers, cytokines, and clinical characteristics, applying Target Trial Emulation to estimate causal treatment effects from observational data. Additionally, it emulates...