Altered ECM and Cell Adhesion in Fragile X

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This presentation delves into the impact of Fragile X Syndrome (FXS) on neurodevelopment, emphasizing the role of FMR1 and FMRP proteins, and extracellular matrix (ECM) disruption in brain disorders. Employing advanced organoid generation protocols, we compare FXS with control groups to identify ECM protein deposition anomalies and disrupted cell adhesion, obtaining insights via proteomics. Discussion focuses on unique human-related defects and ECM dysregulation implications, contrasting...