Autoimmune Diseases (Flipped Classroom) Learning Outcomes (SLOs) By the end of this session, students should be able to: Explain how loss of self-tolerance leads to immune-mediated damage of cardiovascular and respiratory tissues through mechanisms such as molecular mimicry, autoantibody formation, and immune complex deposition. Describe the pathogenesis, clinical features, and complications of Acute Rheumatic Fever (ARF) and Rheumatic Heart Disease (RHD) as examples of autoimmune disease affecting the heart. Describe the cardiovascular and respiratory manifestations of Systemic Lupus Erythematosus (SLE), including pleuritis and pericarditis. Identify the common laboratory markers used in the diagnosis of ARF and SLE, including ASO titers, ANA, and anti-dsDNA antibodies. Outline the basic principles of management of autoimmune diseases, including the roles of NSAIDs, corticosteroids, and immunosuppressive therapie
Autoimmune Diseases (Flipped Classroom) Learning Outcomes (SLOs) By the end of this session, students should be able to: Explain how loss of self-tolerance leads to immune-mediated damage of cardiovascular and respiratory tissues through mechanisms such as molecular mimicry, autoantibody formation, and immune complex deposition. Describe the pathogenesis, clinical features, and complications of Acute Rheumatic Fever (ARF) and Rheumatic Heart Disease (RHD) as examples of autoimmune disease affecting the heart. Describe the cardiovascular and respiratory manifestations of Systemic Lupus Erythematosus (SLE), including pleuritis and pericarditis. Identify the common laboratory markers used in the diagnosis of ARF and SLE, including ASO titers, ANA, and anti-dsDNA antibodies. Outline the basic principles of management of autoimmune diseases, including the roles of NSAIDs, corticosteroids, and immunosuppressive therapie
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This overview addresses the loss of self-tolerance in autoimmune conditions, linking immune injury to heart and lung damage through mechanisms like map mimicry and autoantibodies. It compares cardiac and respiratory case patterns, particularly in ARF and RHD, while recognising SLE-related pleuritis and pericarditis. The focus is on strategic diagnosis and management, interpreting key laboratory results and selecting appropriate treatments such as NSAIDs and corticosteroids, ensuring that...