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Explore the dynamic journey of neuroendocrine (NE) transformation in non-small cell lung cancer (NSCLC) with a focus on ALK-rearranged lung adenocarcinoma (LUAD). This presentation uncovers genomic and transcriptomic shifts through comprehensive sequencing studies, revealing mutation patterns and activated pathways post-therapy. By analyzing disease progression and immune environment changes, we examine the clinical differences from EGFR-mutant LUAD and propose novel therapeutic strategies...