Biotransformation of Xenobiotics

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This coursework introduces students to xenobiotic biotransformation, integral to the ADME framework. Initially, it defines the biotransformation process, highlighting its roles and phases. Students explore the principles, emphasizing how lipophilic substances are transformed into hydrophilic compounds through enzyme-driven reactions that parallel endobiotic metabolism. Focus is placed on Phase I reactions like hydrolysis, reduction, and oxidation, with detailed enzyme workings. Phase II...