Interfacial Proteins Govern Multiphase Coacervate Organization

This research explores biomolecular condensates, focusing on multiphase architectures and the role of αSyn in droplet organization. It addresses mechanisms of architectural transitions regulated by interfacial proteins, hypothesizing surface energy modulation. Using coacervates, confocal microscopy, and theoretical models, findings reveal αSyn-induced partial wetting, snowman-like structures, and interface-driven chaining. Observations include dynamic polymer analogies, reversibility...