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This overview of Systemic Lupus Erythematosus (SLE) defines the condition as a systemic autoimmune disease that attacks healthy tissues. It highlights the global prevalence and burden of SLE, comparing outcomes across different demographic groups and emphasizing its impact on healthcare and quality of life. The development of lupus is explored through genetic and environmental triggers, the role of autoantibodies and immune complexes, and the resulting inflammation and organ injury.