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This presentation addresses the hidden burden of conditions like MPN and ITP, highlighting the need for improved quality of life (QoL) measures. It discusses the importance of patient-reported outcomes (PROs) in clinical settings, particularly through tools like the ITP-PAQ, which assesses the impact of ITP beyond mere platelet counts. The final section focuses on integrating these PROs into routine practice to enhance patient care by tracking baseline scores and treatment adjustments.