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This comprehensive presentation explores Post-Transplant Lymphoproliferative Disorder (PTLD) within the context of Solid Organ Transplantation (SOT). It highlights PTLD's epidemiology, pathophysiology, and the critical risk factors such as EBV seronegativity. With a focus on clinical presentation and diagnostic strategies, it outlines management protocols including ISR, rituximab, and emerging therapies. Additionally, it emphasizes the importance of prevention, surveillance, and addressing...