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Explore the intersection of mitochondrial aging and Ayurveda, bridging ancient Rasayana wisdom with modern science. This outline covers mitochondrial dysfunction as a key aging hallmark, oxidative stress dynamics, and Ayurvedic concepts of Jara, Agni, and Ojas. It highlights rejuvenation therapies, herb evidence, mechanisms like Nrf2/AMPK, lifestyle interventions, and translational steps from biomarkers to personalized clinical applications.