Dosage Compensation and Barr Bodies in Genetics

This lecture explores dosage compensation mechanisms to ensure balanced X-linked gene expression across species, delving into processes like X-inactivation in mammals, male X upregulation in Drosophila, and transcription reduction in C. elegans. Key topics include Lyonization, barr body formation, chromatin changes in X-inactivation, and genes escaping suppression. Clinical implications, such as Turner and Klinefelter syndrome, highlight the significance of dosage balance in understanding sex...