Enhanced gene replacements inKu80 disruptionmutants of the dermatophyte,Trichophytonmentagrophytes Tsuyoshi Yamada1,2, Koichi Makimura1,2, Tatsuya Hisajima1,3, Yumiko Ishihara1, Yoshiko Umeda1 & Shigeru Abe1
Enhanced gene replacements inKu80 disruptionmutants of the
dermatophyte,Trichophytonmentagrophytes
Tsuyoshi Yamada1,2, Koichi Makimura1,2, Tatsuya Hisajima1,3, Yumiko Ishihara1, Yoshiko Umeda1 &
Shigeru Abe1
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This study explores the impact of Ku80 disruption on gene targeting efficiency in the dermatophyte model T. mentagrophytes. The aim is to enhance gene-replacement efficiency by evaluating Ku80 disruption mutants against wild-type backgrounds. The findings suggest that Ku80 disruption facilitates efficient gene replacement, thereby advancing functional genomics and enabling further research into virulence genes.