Exploring Opioid Receptor Roles in Naltrexone-Induced Dysphoria

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This presentation explores naltrexone-induced dysphoria by examining the roles of opioid receptors (MOR, KOR, DOR) in mood regulation. It delves into the pharmacological profile of naltrexone, the association of KOR with dysphoria through the dynorphin system, as well as the potential mood-stabilizing effects of DOR. The content is supported by preclinical studies and discusses receptor imbalances that may contribute to the condition. The conclusion highlights key findings, emphasizes the...