Orlistat's Impact on Renal Health: A Safety Review

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In this educational presentation, we provide an overview and safety review of Orlistat, a medication approved for weight loss available as OTC (60mg ALLI) and prescription (120mg Xenical). We explore the occurrence of kidney-related adverse events over the period from 2007 to 2023, including 8 acute kidney injuries and instances of oxalate nephropathy. Notably, the risk of these events appears not to be dose-dependent. Additionally, potential underreporting of cases suggests the need for...