Frontal Chromatography of Monoclonal Antibodies

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This research presentation delves into the application of hydrogel-based cation exchange (CEX) membranes in monoclonal antibody (mAb) purification, exploring its advantages over traditional cellulose and PES membranes. Key experiments utilized clarified mAb feed materials to assess ionic density, dynamic binding capacity (DBC), and impurity removal under controlled conditions (pH 5.0, conductivity 9 mS/cm). Results indicate hydrogel membranes offer superior DBC and impurity removal...