Innovative Nanoplatforms for Targeted Photoimmunotherapy

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This project addresses critical gaps in antibody-IR700 variability and MSC safety by synthesizing EGFR-targeted nanoparticles (NPs). It hypothesizes a rational design using EGFR peptides and IRDye700DX for clinical-grade near-infrared (NIR) therapies. The in vitro strategy includes testing these NPs on EGFR+ cells and MSCs, using NIR-photoimmunotherapy (PIT) to assess viability and DAMPs production. The three-year plan encompasses NP synthesis, cell validation, and MSC profiling. Expected...