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This lecture introduces the PSDR framework, highlighting its ability to integrate pharmacogenomic insights into oncology trials. With a focus on the mechanistic patient identification and the E-T-C model to refine trial design, we will discuss eligibility principles and the scoring system, ensuring efficacy within pharmacogenomic contexts. The session further explores pharmacokinetic adequacy and target engagement, delineating tumour interactions and microenvironment profiles. By evaluating...