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This lecture explores IGFBPL1's critical role in development, focusing on axon growth in retinal ganglion cells (RGCs). It delves into IGFBPL1's interactions with IGF-1 and its activation of key pathways like PI3K/mTOR and calcium signaling. The session highlights its therapeutic potential in optic nerve regeneration and central nervous system (CNS) repair, providing insights into future research directions for neurological recovery strategies.