Genome editing technologies

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This lecture explores the evolution of DNA cleavage technologies before the advent of CRISPR, emphasizing the significance of targeted interventions. It delves into the specifics of meganucleases, zinc-finger nucleases (ZFNs), and TALENs, comparing their recognition logic, target specificity, and practical challenges. The session highlights a comparative analysis of these methodologies against CRISPR-Cas in terms of design complexity, targeting flexibility, and commercialization potential....