Tacrolimus Use in Kidney Transplantation: An Educational Guide

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This training session offers an insightful exploration of Tacrolimus in kidney transplantation, covering its mechanism as a macrolide calcineurin inhibitor and highlighting findings from the SYMPHONY trial. We'll delve into how Tacrolimus binds to FKBP-12, inhibits calcineurin, and blocks T-cell activation while examining its complex pharmacokinetics and metabolism, influenced by CYP3A4/5 and pharmacogenomics. Participants will gain knowledge on dosing, formulation choices, and managing...