Revealing Gut Microbiome Functions via Structural Proteomics

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This presentation delves into the exploration of the human gut microbiome, utilising a comprehensive GMPS database paired with an AI model for homolog detection. Key highlights include the development of the GMPS database, utilization of AI for identifying functionally similar proteins, and the diversification of phage enzymes. The study addresses challenges in protein annotation due to genetic divergence, showcasing structural genomics' utility in therapeutic enzyme discovery. High-...