Revolutionizing Gut Microbiome Discovery with StAR-MS

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StAR-MS is a powerful tool in metabolite discovery, targeting the complex interactions of the gut microbiota. By integrating biological activity embedding and mass spectrometry data, it efficiently prioritizes active substructures. This has led to the identification of 22 novel metabolites, highlighting unknown microbial reactions. Significantly, the potent AhR agonistic activity of 2-HQ-3-MeS has shown superior effects compared to IAA, with notable immune impacts in vivo, such as an increase...