BDNF Gene Regulation Under Acute Stress

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This study explores how stress influences the regulation of Brain-Derived Neurotrophic Factor (BDNF) through the stress response transcription factor HSF1. Using stressors like Kainic Acid and footshock, and methods such as immunohistochemistry and ChIP-qPCR, the research investigates the activation of HSF1 and its binding to BDNF promoters. The findings reveal HSF1's co-regulation with pCREB in stress responses, extending its role beyond classic heat shock functions. The study concludes that...