Histiocytic Neoplasms: Unraveling Adult-Onset Mysteries 🔬

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This lecture provides a concise, tissue-first approach to adult histiocytic neoplasms, emphasizing WHO/ICC classification, distinction from reactive disease, and recognition of LCH, ECD, RDD, ALK-positive entities, overlaps, and aggressive mimics. It links clinical patterns to myeloid biology, MAPK pathway alterations, and actionable genomics, then translates biopsy, immunophenotype, and molecular testing into targeted treatment strategies. Key takeaways highlight multidisciplinary care,...