Phage Nuclei: Tiny Giants of Bacterial Viruses

This lecture explores jumbo phages, delving into their definition, characteristics, and historical significance in microbiology. It examines the phage nuclei's role in immune evasion and infection, highlighting DNA protection mechanisms and vulnerabilities to RNA-targeting enzymes like Cas13a. The session also covers advancements in genetic engineering, focusing on modifying immune enzymes and manipulating phage replication for research. Lastly, it addresses the broader applications of jumbo...