I have to present for 15minutes about advances in the treatment of metastatic HER2 positive breast cancer

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This overview highlights the evolving treatment landscape for HER2-positive breast cancer, emphasising the importance of sequencing therapies based on disease context and prioritising trastuzumab deruxtecan post-progression. It addresses the complexities of managing resistance, particularly in brain metastases, and the need for tailored patient selection. Furthermore, it explores next-generation strategies, including the assessment of pivotal trials like DESTINY-Breast12 and HER2CLIMB-02,...