This research delves into the interaction between *P. gingivalis* and *F. nucleatum* in OSCC. By examining the synergistic effects on tumour progression, cellular behaviour, and gene expression, the study highlights pathways such as NF-κB, MAPK, and IL-17, emphasising their roles in cancer progression. The findings provide insights into microbiota-induced mechanisms in OSCC and offer potential therapeutic targets, fostering innovative approaches to address inflammation-driven carcinogenesis....