3D Genome Organisation & Cell Fate: Methods & Impact

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This educational course module provides an in-depth overview of 3D genome organisation in early embryos, focusing on the role of HP1a in chromatin architecture. We explore how HP1a is critical during zygotic genome activation, establishing centromeric clustering and affecting the formation of B-compartments. Through a blend of Hi-C, ChIP-seq techniques, and polymer simulations, we unravel the molecular mechanisms and spatial dynamics of HP1's influence on chromatin. The coursework aims to...