HMGB1 as a Biomarker in Type 2 Diabetes
HMGB1 as a Biomarker in Type 2 Diabetes
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This review explores the role of HMGB1 in linking cellular stress to diabetic inflammation, specifically comparing levels in Type 2 Diabetes Mellitus (T2DM) patients and controls. Utilizing PRISMA methods for search and analysis, findings indicate elevated HMGB1 in T2DM, with microvascular effects being more pronounced than macrovascular. However, the heterogeneity of results necessitates further validation to enhance certainty in clinical applications.