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This research investigates the role of tertiary lymphoid organs (TLOs) in kidney transplant challenges, focusing on their immune-mediated contributions to graft failure and fibrosis. Using advanced techniques like spatial transcriptomics and genomic analyses, we aim to analyze TLO heterogeneity, immune cell interactions, and key pathways such as LTβR and NF-κB. Preliminary findings highlight unique gene expression patterns and spatial immune dynamics. The study hypothesizes that TLO pathways...