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This presentation explores the challenge of disinfectant resistance among ICU pathogens, focusing on Gram-negative bacteria as a growing concern. It examines contamination rates, resistance mechanisms, and Karachi-specific epidemiological insights, highlighting their significance. A cross-sectional study evaluates ICU surfaces and patient strains using genomic testing to uncover resistance prevalence and persistence. The findings demonstrate co-selection of disinfectant and antimicrobial...