In Silico Analysis of Tumor Microenvironment

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This research presentation explores the heterogeneity of colon cancer by leveraging RNA-seq data from TCGA-COAD. We classify subtypes and investigate the impact of the tumor microenvironment (TME) and mutations. Hierarchical clustering and analysis of differentially expressed genes (DEGs) identify key mutation patterns in regulatory genes like APC, TP53, and KRAS. With tools like EPIC and xCell, we elucidate TME's role in cancer progression, impacting CD4/CD8 dynamics. Our findings suggest...