Exploring PAI-1's Role in Health and Disease
Exploring PAI-1's Role in Health and Disease
Created using ChatSlide
This dissertation explores the multifunctional role of PAI-1, utilizing the Spn42Dd model for behavioral phenotyping. It addresses significant research questions regarding PAI-1's impact on human health, aging, and disease through an interdisciplinary lens. Key objectives include examining PAI-1 in lipid and fibrotic contexts, and assessing its conservation across species. The work encompasses innovative methodologies, such as a 3-D printed geotaxis device and CRISPR studies, while also...