it is a 30 minute presentation on glutathione, genomics and ## Title **The Genomic Blueprint of Brain Aging: Glutathione, Oxidative Stress & Neuroinflammation** ## Learning Objectives Upon completion of this presentation, participants will be able to: 1. **Describe the role of oxidative stress, reactive oxygen species, and glutathione metabolism in brain aging, neuroinflammation, and cognitive decline.** 2. **Identify key genomic variants affecting glutathione synthesis, utilization, and detoxification, and recognize how gene–gene interactions may amplify susceptibility to oxidative stress and cognitive decline.** 3. **Explain how APOE ε4, TREM2, and microglial-related genomic pathways may interact with impaired antioxidant defenses to influence neuroinflammation and cognitive decline.** 4. **Apply a pathway-based genomic approach to a clinical case to identify potential contributors to oxidative stress and develop individualized strategies for supporting brain health.**
it is a 30 minute presentation on glutathione, genomics and
## Title
**The Genomic Blueprint of Brain Aging: Glutathione, Oxidative Stress & Neuroinflammation**
## Learning Objectives
Upon completion of this presentation, participants will be able to:
1. **Describe the role of oxidative stress, reactive oxygen species, and glutathione metabolism in brain aging, neuroinflammation, and cognitive decline.**
2. **Identify key genomic variants affecting glutathione synthesis, utilization, and detoxification, and recognize how gene–gene interactions may amplify susceptibility to oxidative stress and cognitive decline.**
3. **Explain how APOE ε4, TREM2, and microglial-related genomic pathways may interact with impaired antioxidant defenses to influence neuroinflammation and cognitive decline.**
4. **Apply a pathway-based genomic approach to a clinical case to identify potential contributors to oxidative stress and develop individualized strategies for supporting brain health.**
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This overview explores the interplay between brain aging and the redox–inflammation axis, defining key concepts like ROS and neuroinflammation while linking aging to cognitive decline. It profiles genomic modifiers of antioxidant resilience, highlighting variants and their connections to microglial pathways. Finally, it advocates for a pathway-based clinical strategy, emphasizing personalized approaches to manage risks and enhance cognitive health through case analysis and shared decision-...