Pharmacology and Clinical Use of Local Anaesthetics

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This lecture delves into local anaesthetics, exploring their role in sensation loss, mechanisms via sodium channel blockade, and their distinction from general anaesthesia. It tracks their historical development from cocaine to modern amides like lidocaine and bupivacaine. Clinical applications cover anaesthetic procedures, stress reduction, and postoperative recovery. Key pharmacodynamics focus on potency, pKa values, and metabolism differences between esters and amides. Highlighting...