Autophagy in Depression Modulation

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This presentation explores the connection between stress, autophagy, and depression focusing on the lateral habenula (LHb). Acute stress enhances autophagy, while chronic stress inhibits it, correlating with depression-like behaviors. Mechanisms include key pathways like AMPK activation and mTOR suppression, influencing neuronal adaptation. Antidepressants targeting autophagy, such as rapamycin and Beclin-1 agonists, show promise in reducing depression symptoms. Experimental models like CRS...