Autophagy in Depression Modulation

This presentation explores the connection between stress, autophagy, and depression focusing on the lateral habenula (LHb). Acute stress enhances autophagy, while chronic stress inhibits it, correlating with depression-like behaviors. Mechanisms include key pathways like AMPK activation and mTOR suppression, influencing neuronal adaptation. Antidepressants targeting autophagy, such as rapamycin and Beclin-1 agonists, show promise in reducing depression symptoms. Experimental models like CRS...