journal club presentation

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This research delves into the critical role of lysosomal membranes in cellular integrity and survival. It highlights the function of the LASER protein and TFG in the recruitment of ESCRT complexes necessary for lysosomal repair. The mechanisms involve ESCRT assembly aided by calcium sensors and ATG8 proteins. Furthermore, the study examines the ER-lysosome interaction mediated by TFG, crucial for phospholipid transfer and damage response. TFG's translocation and oligomerisation are essential...