Journal club presentation on a research article.

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This lecture provides a comprehensive analysis of HLA-DPB1 mismatches in hematopoietic stem cell transplantation (HSCT), emphasizing the controversies surrounding HLA-DPB1*0901 as a target for rejection. We will explore the dynamics of T-cells and the recognition pathways involved in shared epitopes. An algorithm for classifying epitope mismatches is discussed, focusing on immunogenic and intermediate groups. Clinical evaluation data from 118 transplants reveal insights into permissive and...