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This study explores the intersection of fertility preservation and cancer control, as detailed in Liu et al. (2026) from Peking Union Medical College Hospital. Results indicate that Arm A shows a significant complete response rate at 12 weeks (77.6% vs 32.8%) and at 24 weeks (98.5% vs 68.8%). Critical appraisal of interim findings suggests potential superiority, although the large effect may be overestimated, with a non-inferiority margin set at 10%. These insights are crucial for clinical...