journal seminar fro a phd student

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This presentation offers a comprehensive overview of the advancements in PROTAC technology, particularly focusing on the role of phenyl-glutarimides (PGs). Beginning with an introduction to Targeted Protein Degradation (TPD) and Cereblon (CRBN) in PROTACs, it outlines the challenges associated with Immunomodulatory drugs (IMiDs). The study showcases innovative synthesis of stable phenyl glutarimides aimed at targeting BET proteins. Through advanced molecular modeling and experimental testing,...